abstract：:Pramipexole, a dopamine D2 receptor agonist, was tested in 174 patients with major depression, with or without melancholia and without psychotic features. Three daily dose levels (0.375 mg, 1.0 mg, and 5.0 mg) were compared to fluoxetine (Prozac) at 20 mg and placebo in a randomized, double-blind, parallel-group study...

journal_title：Depression and anxiety

authors： Corrigan MH,Denahan AQ,Wright CE,Ragual RJ,Evans DL

更新日期：2000-01-01 00:00:00

abstract：:Data from early studies of selective serotonin reuptake inhibitors have shown that these agents are effective in the treatment of social anxiety disorder (social phobia). This review highlights the outcomes of three large clinical trials of paroxetine in patients with social anxiety disorder. In two of the studies, pa...

journal_title：Depression and anxiety

authors： Lydiard RB,Bobes J

更新日期：2000-01-01 00:00:00

abstract：:This study seeks to determine how panic disorder patients with anxiety and depression comorbidity differ from panic disorder patients without comorbidity at the time of presentation for treatment. One-hundred seventy-one panic disorder patients presenting for their initial assessment and treatment at the Payne Whitney...

journal_title：Depression and anxiety

authors： Apfeldorf WJ,Spielman LA,Cloitre M,Heckelman L,Shear MK

更新日期：2000-01-01 00:00:00

abstract：:Electroconvulsive therapy (ECT) involves the use of electrical stimulation to elicit a series of generalized tonic-clonic seizures for therapeutic purposes and is the most effective treatment known for major depression. These treatments have significant neurophysiologic effects, many of which are manifest in the elect...

journal_title：Depression and anxiety

authors： Krystal AD,West M,Prado R,Greenside H,Zoldi S,Weiner RD

更新日期：2000-01-01 00:00:00

abstract：:The psychometric properties of the Social Phobia Anxiety Inventory (SPAI) were assessed in a sample of participants who either had a primary diagnosis of social phobia or were normal volunteers. Positive evidence was obtained on the SPAI's concurrent and predictive convergent validity: it was significantly correlated ...

journal_title：Depression and anxiety

authors： Rodebaugh TL,Chambless DL,Terrill DR,Floyd M,Uhde T

更新日期：2000-01-01 00:00:00

abstract：:There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin (5HT) neurotransmitter systems in depression and anxiety disorders. The majority of evidence supports underactivation of serotonergic function and complex dysregulation of noradrenergic function, most consistent with overactivation o...

journal_title：Depression and anxiety

authors： Ressler KJ,Nemeroff CB

更新日期：2000-01-01 00:00:00

abstract：:Pediatric psychopharmacology is hindered by the relative lack of controlled, empirical clinical trials [Shatzberg and Nemeroff, 1998: Washington, D.C.: The American Psychiatric Press, Inc. p 301-306]. Psychiatric disorders in children and adolescents carry considerable morbidity, impede development, and carry a signif...

journal_title：Depression and anxiety

authors： Weller EB,Weller RA,Davis GP

更新日期：2000-01-01 00:00:00

abstract：:Research on the effects of childhood trauma has been limited by the lack of a comprehensive, reliable, and valid instrument that assesses the occurrence of early traumatic experiences. This paper presents the development and preliminary psychometric properties of an instrument, the Early Trauma Inventory (ETI), for th...

journal_title：Depression and anxiety

authors： Bremner JD,Vermetten E,Mazure CM

更新日期：2000-01-01 00:00:00

abstract：:The increased risk of physical health problems in adult depressed patients has been shown in numerous studies. A recent study of the offspring of depressed parents found similar associations. The purpose of this study is to examine the strength and specificity of the association between depression and physical health ...

journal_title：Depression and anxiety

authors： McAvay G,Nunes EV,Zaider TI,Goldstein RB,Weissman MM

更新日期：1999-01-01 00:00:00

abstract：:Ninety-three patients, including 47 patients with Generalized Anxiety Disorder (GAD) and 46 patients with Major Depression (MD), were entered into recent clinical trials. Clinicians acknowledge that during the initial screening process, clear separation between depressed and anxious patients may be difficult. By using...

journal_title：Depression and anxiety

authors： Freeman AM 3rd,Kablinger AS,Rolland PD,Brannon GE

更新日期：1999-01-01 00:00:00

abstract：:In spite of substantial advances in the treatment of major depression by pharmacotherapy and other means, a significant number of depressed patients require hospitalization. In the context of the Jerusalem Collaborative Depression Project, possible precipitants of psychiatric hospitalization were sought in a cohort of...

journal_title：Depression and anxiety

authors： Lerer B,Shapira B,Bloch M,Hanin B,Trudart T,Alexander JR,Popper M,Braun D,Segman RH,Ritsner M

更新日期：1999-01-01 00:00:00

abstract：:The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age-matched female control group; and in male combat veterans with PTSD and compared to three groups of age-matched male control subjects. Sensory gating of the P1 potential was d...

journal_title：Depression and anxiety

authors： Skinner RD,Rasco LM,Fitzgerald J,Karson CN,Matthew M,Williams DK,Garcia-Rill E

更新日期：1999-01-01 00:00:00

abstract：:We successfully treated a 46-year-old narcoleptic woman suffering from atypical depression with bupropion hydrochloride. Diagnostic evaluation revealed a Beck Depression Inventory (BDI) score of 24, a short nocturnal REM-sleep latency, subjective and objective sleepiness (mean sleep latency (MSL) = 1.8 minutes), and t...

journal_title：Depression and anxiety

authors： Rye DB,Dihenia B,Bliwise DL

更新日期：1998-01-01 00:00:00

abstract：:This report describes the reactivation of a posttraumatic stress disorder (PTSD) after a minor head injury in two young women who had recovered from extreme stress caused by sexual abuse during adolescence. Intrusive thoughts, images, dreams, and phobic avoidance bear a direct relationship to the specific circumstance...

journal_title：Depression and anxiety

authors： Berthier ML,Kulisevsky J,Fernández Benitez JA,Gironell A

更新日期：1998-01-01 00:00:00

abstract：:This study sought to describe clinical and demographic characteristics differentiating patients with DSM-III-R simple phobias comorbid with one or more of five DSM-III-R index anxiety disorders as compared with those with the index diagnoses alone. From 711 subjects participating in a multicenter, longitudinal, natura...

journal_title：Depression and anxiety

authors： Goisman RM,Allsworth J,Rogers MP,Warshaw MG,Goldenberg I,Vasile RG,Rodriguez-Villa F,Mallya G,Keller MB

更新日期：1998-01-01 00:00:00

abstract：:Depressive symptoms, due either major depression or clinically significant, subsyndromal depression, occur commonly in the course of Alzheimer's disease. For a variety of clinical and methodological reasons, this remains an area that begs for new investigation. At the very least, these depressive symptoms should be vi...

journal_title：Depression and anxiety

authors： Tune LE

更新日期：1998-01-01 00:00:00

abstract：:The objective was to present naturalistic 1-year follow-up information of 96 child and adolescent outpatients with major depressive disorder who had been randomized in an 8-week double-blind, placebo-controlled trial of fluoxetine. Subjects were children and adolescents, ages 8-18 years, who were entered in a randomiz...

journal_title：Depression and anxiety

authors： Emslie GJ,Rush AJ,Weinberg WA,Kowatch RA,Carmody T,Mayes TL

更新日期：1998-01-01 00:00:00

abstract：:Research has shown that obsessive compulsive disorder (OCD) is related to structural and functional abnormalities in the brain, and several authors have organized these findings into theories of OCD neuropsychiatric dysfunction. In this paper, these theories were used to develop a neural network model of OCD. OCD symp...

journal_title：Depression and anxiety

authors： Ownby RL

更新日期：1998-01-01 00:00:00

abstract：:This study replicated the factor structure of the Parental Bonding Instrument (PBI), and explored the relationships of PBI scores to demographic variables. We investigated the association between parental bonding in the parents measured by the PBI, and lifetime history of depression in their children assessed by the I...

journal_title：Depression and anxiety

authors： Uehara T,Sato T,Sakado K,Someya T

更新日期：1998-01-01 00:00:00

abstract：:Thus, there appears to be a large variety of approaches to refractory bipolar depression. In contrast to several decades ago, wherein augmentation of lithium with antidepressants and neuroleptics was essentially the only treatment mode available, a panoply of treatment options now exist. However, their relative effica...

journal_title：Depression and anxiety

authors： Post RM,Leverich GS,Denicoff KD,Frye MA,Kimbrell TA,Dunn R

更新日期：1997-01-01 00:00:00

abstract：:In this analysis we examined studies of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) to compare efficacy and drop-out rates. Frequency of reported side effects was also studied. Using Medline, we located 36 clinical trials of TCAs and SSRIs in a double-blind comparison. We perfo...

journal_title：Depression and anxiety

authors： Steffens DC,Krishnan KR,Helms MJ

更新日期：1997-01-01 00:00:00

abstract：:The purpose of this study was to correlate subjective sleep characteristics based on questionnaire response, and objective sleep EEG features based on polysomnography, in 52 patients with major depressive disorders (MDD) and 49 healthy controls. With the exception of the number of awakenings, subjective and objective ...

journal_title：Depression and anxiety

authors： Armitage R,Trivedi M,Hoffmann R,Rush AJ

更新日期：1997-01-01 00:00:00

abstract：:Since the introduction of the concept of social anxiety (or phobia) to the American nosological system in DSM-III (1980), it has become increasingly apparent that the condition is also prevalent in other cultures. In Japan, for example, the condition, called taijinkyofusho (usually abbreviated as TKS in English), is w...

journal_title：Depression and anxiety

authors： Chang SC

更新日期：1997-01-01 00:00:00

abstract：:Although global clinical rating scales have been a mainstay of clinical research, little is known about the relationship between these measures and other assessment modalities. The present study examined the Clinician's Severity Rating (CSR) from the Anxiety Disorders Interview Schedule in a sample of 186 social phobi...

journal_title：Depression and anxiety

authors： Hope DA,Laguna LB,Heimberg RG,Barlow DH

更新日期：1996-01-01 00:00:00

abstract：:The selective serotonin reuptake inhibitors (SSRIs) are recognized as effective as and better tolerated than older antidepressant therapies and have become the drugs of choice in the treatment of mild to moderate depression. However, there is a clinical impression that the SSRIs are less effective than older therapies...

journal_title：Depression and anxiety

authors： Schatzberg AF

更新日期：1996-01-01 00:00:00

abstract：:Depressed patients who rapidly metabolize antidepressants may be common, and may not respond to even high doses of antidepressants if subtherapeutic plasma levels are produced. Rapid metabolizers (RMs) are identifiable if patients are on tricyclic antidepressants (TCAs), and TCA plasma levels (commonly available) are ...

journal_title：Depression and anxiety

authors： Kraus RP,Diaz P,McEachran A

更新日期：1996-01-01 00:00:00